The Syntheses Of Fused Cyclic 5/6-Membered Ring Lactams Via Enamine Hydrogenation
Table 1:
| Position |
13C (ppm) |
1H (mult., ΣH)) |
| 2 (CDCl3) |
3 (MeOD) |
2 (CDCl3) |
3 (MeOD) |
| 1-N |
27.70 |
28.24 |
2.57 (s, 3H) |
2.52 (s, 3H) |
| 2 |
171.99 |
170.89 |
- |
- |
| 3 |
54.96 |
65.65 |
3.78-3.79 (d, 1H) |
3.35-3.37 (d, 1H) |
| 4 |
52.37 |
41.86- |
3.32-3.36 (m, 1H) |
2.52-2.54 (m, 1H) |
| 5 |
65.06 |
69.35 |
4.66-4.68 (d, 1H) |
4.02-4.04 (d, 1H) |
| 6-N |
- |
51.65 |
- |
3.47 (s, 3H) |
| 7 |
172.01 |
173.16 |
- |
- |
| 8 |
168.53 |
35.79 |
- |
2.37-2.45 (m, 2H) |
| 9 |
171.28 |
- |
- |
- |
| 10 |
167.50 |
- |
- |
- |
| OCH3 |
51.29 |
55.42 |
3.69 (s, 3H) |
3.80 (s, 3H) |
| 1’ |
138.40 |
130.53 |
- |
- |
| 2’ |
128.60 |
114.43 |
7.35-7.42 (m, 5H) |
6.88-6.91 (d, 2H) |
| 3’ |
128.44 |
128.62 |
7.10-7.12 (d, 2H) |
| 4’ |
127.67 |
159.81 |
- |
| 5’ |
128.44 |
128.62 |
7.10-7.12 (d, 2H) |
| 6’ |
128.60- |
114.43 |
6.88-6.91 (d, 2H)- |
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